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Since its creation, Institut Roche has translated its expertise into numerous successful scientific publications

Preserving information while respecting privacy through an information theoretic framework for synthetic health data generation.NPJ Digit Med. 8(1):49.

Sella N, Guinot F, Lagrange N, Albou LP, Desponds J, Isambert H. (2025)

https://doi.org/10.1038/s41746-025-01431-6
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Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic miceHaematologica

Sefiane T, McCluskey G, Clavel M, Maynadié H, Peyron I, David T, Brochier C, Saller F, Khamari M, Denis CV, Christophe OD, Lenting PJ, Muczynski V, Casari C.( 2025)

https://doi.org/10.3324/haematol.2024.286982
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In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii Antimicrob Agents Chemother. 69(5):e0153524

Lacroix M, Moreau J, Zampaloni C, Bissantz C, Mirfendereski H, Shirvani H, Marchand S, Couet W, Chauzy A. (2025)

https://doi.org/10.1038/s41746-025-01431-6
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Hyperglycemia and circadian disruption lead to retinal dysfunction in a stabilized colony of the fat sand rat Psammomys obesus Biochim Biophys Acta Mol Basis Dis. 1870(4):167118

Estay-Ahumada CE, Verra DM, Roux M, Sassone F, Felder-Schmittbuhl MP, Klopp C, Ciocca D, Moal ML, Hicks D. (2024)

https://doi.org/10.1016/j.bbadis.2024.167118
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Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab. J Thromb Haemost 22(1):112-125

Atsou S, Schellenberg C, Lagrange J, Lacolley P, Lenting PJ, Denis CV, Christophe OD, Regnault V.. (2024).

https://doi.org/10.1016/j.jtha.2023.09.017
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Impact of covariate model building methods on their clinical relevance evaluation in population pharmacokinetic analyses: comparison of the full model, stepwise covariate model (SCM) and SCM+ approaches. J Pharmacokinet Pharmacodyn 51(6):653-670.

Philipp, M., Buatois, S., Retout, S, Mentré F (2024).

https://doi.org/10.1007/s10928-024-09911-0
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Simulation-based evaluation of the Pharmpy Automatic Model Development tool for population pharmacokinetic modeling in early clinical drug development CPT Pharmacometrics Syst Pharmacol (10):1707-1721

Duvnjak Z, Schaedeli Stark F, Cosson V, Retout S, Schindler E, Abrantes JA (2024)

https://doi.org/10.1002/psp4.13213
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Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod Clinical and Translational Science. (8):e13896

Jiang, Q., Zhang, Y., Duan, D., Retout, S., Upmanyu, R., Glavini, K., Triyatni, M., Zhu, Y., Grippo, J., Jin, Y (2024).

https://doi.org/10.1111/cts.13896
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Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii. Int J Antimicrob Agents. 64(1):107189.

Lacroix M, Moreau J, Zampaloni C, Bissantz C, Shirvani H, Marchand S, Couet W, Chauzy A.

https://doi.org/10.1016/j.ijantimicag.2024.107189
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