Our publications - Institut Roche

Sella N, Guinot F, Lagrange N, Albou LP, Desponds J, Isambert H. (2025)

Preserving information while respecting privacy through an information theoretic framework for synthetic health data generation.NPJ Digit Med. 8(1):49.

https://doi.org/10.1038/s41746-025-01431-6

Sefiane T, McCluskey G, Clavel M, Maynadié H, Peyron I, David T, Brochier C, Saller F, Khamari M, Denis CV, Christophe OD, Lenting PJ, Muczynski V, Casari C.( 2025)

Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic miceHaematologica

https://doi.org/10.3324/haematol.2024.286982

Lacroix M, Moreau J, Zampaloni C, Bissantz C, Mirfendereski H, Shirvani H, Marchand S, Couet W, Chauzy A. (2025)

In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii Antimicrob Agents Chemother. 69(5):e0153524

https://doi.org/10.1038/s41746-025-01431-6

Estay-Ahumada CE, Verra DM, Roux M, Sassone F, Felder-Schmittbuhl MP, Klopp C, Ciocca D, Moal ML, Hicks D. (2024)

Hyperglycemia and circadian disruption lead to retinal dysfunction in a stabilized colony of the fat sand rat Psammomys obesus Biochim Biophys Acta Mol Basis Dis. 1870(4):167118

https://doi.org/10.1016/j.bbadis.2024.167118

Atsou S, Schellenberg C, Lagrange J, Lacolley P, Lenting PJ, Denis CV, Christophe OD, Regnault V.. (2024).

Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab. J Thromb Haemost 22(1):112-125

https://doi.org/10.1016/j.jtha.2023.09.017

Philipp, M., Buatois, S., Retout, S, Mentré F (2024).

Impact of covariate model building methods on their clinical relevance evaluation in population pharmacokinetic analyses: comparison of the full model, stepwise covariate model (SCM) and SCM+ approaches. J Pharmacokinet Pharmacodyn 51(6):653-670.

https://doi.org/10.1007/s10928-024-09911-0

Duvnjak Z, Schaedeli Stark F, Cosson V, Retout S, Schindler E, Abrantes JA (2024)

Simulation-based evaluation of the Pharmpy Automatic Model Development tool for population pharmacokinetic modeling in early clinical drug development CPT Pharmacometrics Syst Pharmacol (10):1707-1721

https://doi.org/10.1002/psp4.13213

Jiang, Q., Zhang, Y., Duan, D., Retout, S., Upmanyu, R., Glavini, K., Triyatni, M., Zhu, Y., Grippo, J., Jin, Y (2024).

Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod Clinical and Translational Science. (8):e13896

https://doi.org/10.1111/cts.13896

Lacroix M, Moreau J, Zampaloni C, Bissantz C, Shirvani H, Marchand S, Couet W, Chauzy A.

Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii. Int J Antimicrob Agents. 64(1):107189.

https://doi.org/10.1016/j.ijantimicag.2024.107189