“To support drug development defining the right dose for every patient via modeling and simulation technics.”
Your role at Institut Roche and brief presentation of your professional background:
I have been working for Roche since 2009, based within the Institut Roche since 2011. During those years, I have been supporting pRED (Roche Pharma Research and Early Development) project developments as a pharmacometrician within the Pharmaceutical Sciences Department. My role is to develop mathematical models to describe pharmacokinetic (PK), PK-pharmacodynamic (PD), and PK-Efficacy or Safety relationships using data from clinical studies (phase 1 to phase 3). Using those models, I have been supporting, dose and dosing regimen selection for drug development projects in various diseases, including Alzheimer’s Disease (Gantenerumab), Hemophilia A (Hemlibra) and Flu (Xofluza). I have also been supporting drug registrations and labellings in front of Health Authorities (FDA, EMA, PMDA, NMPA, etc..).
My Focus at Institut Roche:
Optimal design for both population and individual parameter estimation in nonlinear mixed effect models; Model selection and model averaging methods in dose finding trials analyzed by nonlinear mixed effect models; Covariate model selection and associated uncertainty for covariate inference in pharmacometric analyses; Application of those methods to the analysis of drugs under development.